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FDX1-dependent and Independent Mechanisms of Elesclomol-mediated Intracellular Copper Delivery
Recent studies have uncovered the therapeutic potential of elesclomol (ES), a copper-ionophore, for copper deficiency disorders. …
Mohammad Zulkifli, Amy N. Spelbring, Yuteng Zhang, Shivatheja Soma, Si Chen, Luxi Li, Trung Le, Vinit Shanbhag, Michael J. Petris, Tai-Yen Chen, Martina Ralle, David P. Barondeau, Vishal M. Gohil
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Subcellular redox responses reveal different Cu-dependent antioxidant defenses between mitochondria and cytosol
Excess intracellular Cu perturbs cellular redox balance and thus causes diseases. However, the relationship between cellular redox …
Yuteng Zhang, Meng-Hsuan Wen, Guoting Qin, Chengzhi Cai, Tai-Yen Chen
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Dissection of Interaction Kinetics through Single-Molecule Interaction Simulation
The ability to extract kinetic interaction parameters from single-molecule fluorescence resonance energy transfer trajectories without …
Manhua Pan, Yuteng Zhang, Guangjie Yan, Tai-Yen Chen
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